|
Hypothyroidism
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Women with the lowest ovarian reserves had higher levels of TPO Ab, with a positive trend of this antibody overtime in comparison to other quartiles, indicating that this group may be at a higher risk of hypothyroidism over time.
|
31064360 |
2019 |
|
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Women positive for TPOAb are at a significant risk of developing hypothyroidism during pregnancy and postpartum.
|
28102101 |
2017 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
With this approach, TPO antibody titers over 17 IU/ml indicated hypothyroidism with a 90% sensitivity and 75% sensibility.
|
28954485 |
2017 |
|
Hypothyroidism
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
We investigated an adopted boy with iodide organification defect, who presented with florid hypothyroidism at the age of 4 mo, poorly complied with thyroxine treatment, and developed a compressive goiter necessitating partial resection at the age of 12 yr. Biochemical studies revealed the absence of TPO activity in the resected tissue.
|
1401057 |
1992 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
We collected information on thyroid-specific phenotypes (TSH, T3, T4, fT4, TgAb, TPOAb, thyroid volume) and other clinical phenotypes (age, body surface area, number of hypothyroidism symptoms, blood pressure) from 290 patients with HT without levothyroxine (LT4) therapy with the aim to test for correlations between thyroid-specific and clinical phenotypes.
|
30332318 |
2019 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
To our knowledge, this is first study reporting the role of TPO gene with hypothyroidism in a population of Asian Indian origin.
|
24420335 |
2014 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
To assess the effect of iodine on hypothyroidism in TPO Ab positive or negative populations, the weighted prevalence of hypothyroidism was assessed in each population according to UIC or estimated iodine intake subgroups.
|
30276524 |
2019 |
|
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thyroid abnormalities were detected in 45 (52.3%) patients, including 28 (32.3%) hypothyroidism, 3 (3.5%) hyperthyroidism and 20 (23.3%) thyroperoxidase antibody positivity.
|
31780218 |
2019 |
|
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Three siblings with goitre and latent to mild hypothyroidism were suspected of having thyroid peroxidase (TPO) abnormality.
|
12864797 |
2003 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
Therefore the aim was to analyze presence of anti-TPO antibodies in hypothyroidism patients in Gujarat.
|
26963610 |
2016 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
There were no clear differences between groups for low birthweight (average RR 0.56; 95% CI 0.26 to 1.23, two trials, 377 infants, no statistical heterogeneity, low-quality evidence), neonatal hypothyroidism/elevated thyroid-stimulating hormone (TSH) (average RR 0.58; 95% CI 0.11 to 3.12, two trials, 260 infants, very low-quality evidence) or the adverse effect of elevated neonatal thyroid peroxidase antibodies (TPO-ab) (average RR 0.61; 95% CI 0.07 to 5.70, one trial, 108 infants, very low-quality evidence).
|
28260263 |
2017 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
The risk of developing hypothyroidism was higher in the patients with repeated allo-HSCTs (P=0.024) and with positive TPO antibodies (P=0.045).
|
28433882 |
2017 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
The proportion of hypothyroidism was calculated and thyroid peroxidase antibodies (TPO) in serum were measured.
|
27861716 |
2017 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
The prevalence of thyroid peroxidase-Ab was higher in both hypothyroid and hyperthyroid cases than in controls.
|
20956436 |
2011 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
The main outcomes were TPOAb concentrations and positivity, thyroid hormone concentrations (TSH, free T4), and clinical thyroid diseases (subclinical and overt hypothyroidism and goiter).
|
25719932 |
2015 |
|
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
LHGDN |
The identified TPO gene mutation (R314W) is very likely the genetic cause for hypothyroidism in the reported child.
|
19189706 |
2008 |
|
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The identified TPO gene mutation (R314W) is very likely the genetic cause for hypothyroidism in the reported child.
|
19189706 |
2008 |
|
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The compound heterozygotic mutations of the TPO gene (c.2268-2269 insT and c.2090 G>A) in two patients with congenital goiters hypothyroidism were demonstrated.
|
26406404 |
2015 |
|
Hypothyroidism
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Previous studies have shown that thyroid peroxidase antibody is associated with homocysteine levels in hypothyroidism.
|
29966154 |
2020 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
P38/TRHr-Dependent Regulation of TPO in Thyroid Cells Contributes to the Hypothyroidism of Triclosan-Treated Rats.
|
29462796 |
2018 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
No thyroid antibodies were present in the affected siblings in family A, while the male in family B with hypothyroidism had antibodies against thyroid peroxidase at diagnosis.
|
15290270 |
2004 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
Nivolumab-induced immune thrombocytopenia and hypothyroidism were suspected based on the presence of platelet-associated IgG, an increased level of autoantibodies to thyroglobulin and thyroid peroxidase and an enlarged thyroid gland.
|
29260625 |
2018 |
|
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
It is characterized as both cellular immune responses with T, B cells infiltrating to the thyroid gland followed by hypothyroidism as a result of destruction of the thyroid follicles and fibrous replacement of the parenchymal tissue, as well as immune response for TPO and Tg-antibody production.
|
30093941 |
2018 |
|
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
Isolated hypothyroidism was rare (n=2) and late (median: 30 weeks).Three patients had anti-TPO antibodies.
|
31005502 |
2019 |